{"date_updated":"2024-06-03T12:11:12Z","date_created":"2024-05-29T10:06:47Z","title":"Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients","language":[{"iso":"eng"}],"place":"Basel","citation":{"chicago-de":"Steiner, Denise, Alexander Meyer, Isabell Immohr und Miriam Pein-Hackelbusch. 2024. Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients. <i>Pharmaceutics</i> 16, Nr. 5. doi:<a href=\"https://doi.org/10.3390/pharmaceutics16050658\">10.3390/pharmaceutics16050658</a>, .","van":"Steiner D, Meyer A, Immohr I, Pein-Hackelbusch M. Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients. Pharmaceutics. 2024;16(5).","ama":"Steiner D, Meyer A, Immohr I, Pein-Hackelbusch M. Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients. <i>Pharmaceutics</i>. 2024;16(5). doi:<a href=\"https://doi.org/10.3390/pharmaceutics16050658\">10.3390/pharmaceutics16050658</a>","din1505-2-1":"<span style=\"font-variant:small-caps;\">Steiner, Denise</span> ; <span style=\"font-variant:small-caps;\">Meyer, Alexander</span> ; <span style=\"font-variant:small-caps;\">Immohr, Isabell</span> ; <span style=\"font-variant:small-caps;\">Pein-Hackelbusch, Miriam</span>: Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients. In: <i>Pharmaceutics</i> Bd. 16. Basel, MDPI (2024), Nr. 5","ieee":"D. Steiner, A. Meyer, I. Immohr, and M. Pein-Hackelbusch, “Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients,” <i>Pharmaceutics</i>, vol. 16, no. 5, 2024, doi: <a href=\"https://doi.org/10.3390/pharmaceutics16050658\">10.3390/pharmaceutics16050658</a>.","mla":"Steiner, Denise, et al. “Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients.” <i>Pharmaceutics</i>, vol. 16, no. 5, 2024, <a href=\"https://doi.org/10.3390/pharmaceutics16050658\">https://doi.org/10.3390/pharmaceutics16050658</a>.","short":"D. Steiner, A. Meyer, I. Immohr, M. Pein-Hackelbusch, Pharmaceutics 16 (2024).","chicago":"Steiner, Denise, Alexander Meyer, Isabell Immohr, and Miriam Pein-Hackelbusch. “Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients.” <i>Pharmaceutics</i> 16, no. 5 (2024). <a href=\"https://doi.org/10.3390/pharmaceutics16050658\">https://doi.org/10.3390/pharmaceutics16050658</a>.","apa":"Steiner, D., Meyer, A., Immohr, I., &#38; Pein-Hackelbusch, M. (2024). Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients. <i>Pharmaceutics</i>, <i>16</i>(5). <a href=\"https://doi.org/10.3390/pharmaceutics16050658\">https://doi.org/10.3390/pharmaceutics16050658</a>","bjps":"<b>Steiner D <i>et al.</i></b> (2024) Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients. <i>Pharmaceutics</i> <b>16</b>.","ufg":"<b>Steiner, Denise u. a.</b>: Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients, in: <i>Pharmaceutics</i> 16 (2024), H. 5.","havard":"D. Steiner, A. Meyer, I. Immohr, M. Pein-Hackelbusch, Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients, Pharmaceutics. 16 (2024)."},"type":"scientific_journal_article","keyword":["e-tongues","performance","qualification","taste masking","bitterness","dosage forms","drug formulations"],"main_file_link":[{"url":"https://www.mdpi.com/1999-4923/16/5/658","open_access":"1"}],"status":"public","publication_status":"published","quality_controlled":"1","article_type":"review","intvolume":"        16","year":"2024","_id":"11492","user_id":"83781","department":[{"_id":"DEP4028"}],"publisher":"MDPI","doi":"10.3390/pharmaceutics16050658","author":[{"full_name":"Steiner, Denise","first_name":"Denise","last_name":"Steiner"},{"first_name":"Alexander","last_name":"Meyer","full_name":"Meyer, Alexander","id":"58585"},{"first_name":"Isabell","last_name":"Immohr","full_name":"Immohr, Isabell"},{"full_name":"Pein-Hackelbusch, Miriam","orcid":"0000-0002-7920-0595","id":"64952","first_name":"Miriam","last_name":"Pein-Hackelbusch"}],"issue":"5","publication_identifier":{"issn":["1999-4923 "]},"publication":"Pharmaceutics","abstract":[{"text":"\r\nfirst_page\r\nsettings\r\nOrder Article Reprints\r\nOpen AccessReview\r\nCritical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients\r\nby Denise Steiner\r\n1 [ORCID] , Alexander Meyer\r\n2, Laura Isabell Immohr\r\n3 and Miriam Pein-Hackelbusch\r\n2,* [ORCID]\r\n1\r\nInstitute of Pharmaceutical Technology and Biopharmaceutics, University of Muenster, Corrensstraße 48, 48149 Muenster, Germany\r\n2\r\nInstitute for Life Science Technologies (ILT.NRW), Ostwestfalen-Lippe University of Applied Sciences and Arts, Campusallee 12, 32657 Lemgo, Germany\r\n3\r\nNextPharma Germany Bidco GmbH, Hildebrandstrasse 12, 37081 Goettingen, Germany\r\n*\r\nAuthor to whom correspondence should be addressed.\r\nPharmaceutics 2024, 16(5), 658; https://doi.org/10.3390/pharmaceutics16050658\r\nSubmission received: 26 March 2024 / Revised: 3 May 2024 / Accepted: 9 May 2024 / Published: 15 May 2024\r\nDownload\r\nkeyboard_arrow_down\r\nBrowse Figures\r\nVersions Notes\r\n\r\nAbstract\r\nIn this review, we aim to highlight the advantages, challenges, and limitations of electronic tongues (e-tongues) in pharmaceutical drug development. The authors, therefore, critically evaluated the performance of e-tongues regarding their qualification to assess peroral formulations containing bitter active pharmaceutical ingredients. A literature search using the keywords ‘electronic’, ‘tongue’, ‘bitter’, and ‘drug’ in a Web of Science search was therefore initially conducted. Reviewing the publications of the past decade, and further literature where necessary, allowed the authors to discuss whether and how e-tongues perform as expected and whether they have the potential to become a standard tool in drug development. Specifically highlighted are the expectations an e-tongue should meet. Further, a brief insight into the technologies of the utilized e-tongues is given. Reliable protocols were found that enable (i) the qualified performance of e-tongue instruments from an analytical perspective, (ii) proper taste-masking assessments, and (iii) under certain circumstances, the evaluation of bitterness.\r\n","lang":"eng"}],"oa":"1","volume":16}